Downstream processing of cell culture-derived virus particles

Downstream processing of cell culture-derived animal viruses

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Extraction and downstream processing of plant-derived recombinant proteins.

Plants offer the tantalizing prospect of low-cost automated manufacturing processes for biopharmaceutical proteins, but several challenges must be addressed before such goals are realized and the most significant hurdles are found during downstream processing (DSP). In contrast to the standardized microbial and mammalian cell platforms embraced by the biopharmaceutical industry, there are many ...

Inactivated African Horse Sickness Virus Cell Culture Vaccine

Re-design of Downstream Processing Techniques for Nanoparticulate Bioproducts

There has been much interest generated in the recovery of nanoparticulate (nanoparticle) bioproducts(Second generation of biotechnological products) such as plasmid DNA and viruses as putative gene therapyvectors, macromolecular assemblies as drug delivery vehicles and virus-like particles as vaccine components.Such product must be manufactured in advanced stages of purity, ma...

Cell Culture and Virus

Canine distemper virus (CDV), a morbillivirus (Paramyxoviridae family) is the causative agent of a serious infection in dogs and other carnivores [2] and has been shown to be antigenically related to other members of the genus [13]. CDV infection in dogs generally is transmitted by inhalation of infectious aerosols. CDV causes acute generalized infection or chronic localized and persistent infe...